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KMID : 0359920130320040153
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Korean Journal of Nephrology
2013 Volume.32 No. 4 p.153 ~ p.157
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Clinical usefulness of kidney biopsy in liver transplant recipients with renal impairment
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Lee Jong-Hoon
Cho Yul-Hee
Ryu Seung-Jee
Kim Sin-Seung
Lee Youn-Hee
Jang In-Ae
Choi Bum-Soon
Choi Jong-Young
Kim Dong-Goo
Choi Yeong-Jin
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Abstract
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Background: Chronic kidney disease is a common complication after liver transplantation. In this study, we analyzed the results of kidney biopsy in liver transplantation recipients with renal impairment.
Methods: Between 1999 and 2012, 544 liver transplants were performed at our hospital. We retrospectively analyzed the clinical and histological data of 10 liver transplantation recipients referred for kidney biopsy.
Results: The biopsies were performed at a median of 24.5 months (range, 3?73 months) after liver transplantation. The serum creatinine level was 1.8170.5 mg/dL at the time of kidney biopsy. There were no immediate complications. The most common diagnosis was glomerulonephritis (GN), such as immunoglobulin A nephropathy (n¼4), mesangial proliferative GN (n¼1), focal proliferative GN (n¼1), and membranous GN (n¼1). Typical calcineurin inhibitor (CNI)-induced nephrotoxicity was detected in three cases (30%). Chronic tissue changes such as glomerulosclerosis, interstitial fibrosis, and tubular atrophy were present in 90%, 80%, and 80% of cases, respectively, and mesangial proliferation was detected in 40% of cases. We began treatment for renal impairment based on the result of kidney biopsy; for example, angiotensin-receptor blockers or steroids were prescribed for GN, and the CNI dosewas reduced for CNI nephrotoxicity. As a result, eight of 10 patients showed improvement in glomerular filtration rate, but two progressed to end-stage renal disease.
Conclusion: Kidney biopsy is a safe and effective method for determining the cause of renal impairment after liver transplantation. Management of patients based on the result of kidney biopsy may improve renal outcomes.
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KEYWORD
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Calcineurin inhibitor, Chronic kidney disease, Kidney biopsy, Liver transplantation
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